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The effects of carbon dust inhalation on the bone marrow derived (B) and thymus derived (T) lymphocyte populations of spleen and mediastinal lymph node (MLN) cultures were examined. The concanavalin A (Con A) responsive cell population (T cells) in the spleen was found to be depressed after 7 days of pre exposure to carbon dust.
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Similar results were obtained when the antigens were administered by intravenous or intraperitoneal route. In contrast 4 days of pre exposure to carbon dust increased the number of antibody forming cells in the mediastinal lymph nodes. However, this effect was transient and was not significant when the carbon pre exposure was continued for 15 days.
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